New paper on development of immune memory of the skin

The prestigious journal Science Immunoloy has just published a study entitled “Metabolic rewiring tunes dermal macrophages in staphylococcal skin infections” which was performed by German-Swiss group of investigators led by PILOT director Philipp Henneke and including several other PILOT scientists.

The researchers discovered that early in staphylococcal skin infection, granulocyte-macrophage colony-stimulating factor (GM-CSF) produced by γδ T cells diverts macrophages away from a homeostatic M-CSF- and HIF-1α dependent program. This metabolically rewires macrophages for maximal inflammatory activity, in particular via itaconate formation. This enables both timely clearance of bacteria and local immune memory to protect against secondary infections.

The paper can be found here.

Congratulations to the whole team!