B03
Perinatal development of dermal macrophage diversity
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In this project, we combine lineage tracing of highly-dedicated dermal macrophages with proficiency in single cell epigenomics. We explore factors driving perinatal development of dermal macrophages diversity with a focus on 1) identification of novel macrophages niches in the dermis; 2) perinatal competition between fetal and bone-marrow-derived cells for immunological niches in the dermis; 3) limits of and cues for dermal Mφ subset plasticity. Single-cell transcriptomics and epigenomics, fate mapping, and high-resolution tissue imaging will be employed.