Perinatal fate decisions of macrophages in protected tissues
This project expands our previous work on myeloid cell development starting in embryonic life by delineating patterns of ontogeny, underlying transcriptional programs and molecular signals driving the perinatal development of parenchymal (pMφ) as opposed to perivascular Mφ (periMφ). The project focuses on tissues that are largely protected from direct microbial contact (brain, heart, kidney) and exploits novel fate mapping systems, single-cell profiling and cell-specific mutants to define pre- to postnatal check points, tissue-specific niches and cues that modify the fate and function of pMφ and periMφ.
Team
Publications
The niche matters: origin, function and fate of CNS-associated macrophages during health and diseaseAdrià Dalmau Gasull, Martina Glavan, Sai K. Reddy Samawar, Kishan Kapupara, Joe Kelk, Marina Rubio, Stefano Fumagalli, Lydia Sorokin, Denis Vivien & Marco Prinz 2024 Acta Neuropathologica
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Microglia out of place—mapping macrophages across the developing human bodyRoman Sankowski & Marco Prinz 2023 Cellular & Molecular Immunology volume
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Multiomic spatial landscape of innate immune cells at human central nervous system bordersRoman Sankowski, Patrick Süß, Alexander Benkendorff, Chotima Böttcher, Camila Fernandez-Zapata, Chintan Chhatbar, Jonathan Cahueau, Gianni Monaco, Adrià Dalmau Gasull, Ashkan Khavaran, Jürgen Grauvogel, Christian Scheiwe, Mukesch Johannes Shah, Dieter Henrik Heiland, Oliver Schnell, Filiz Markfeld-Erol, Mirjam Kunze, Robert Zeiser, Josef Priller & Marco Prinz 2023 Nature Medicine
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Metabolic rewiring tunes dermal macrophages in staphylococcal skin infectionForde AJ, Kolter J, Zwicky P, Baasch S, Lohrmann F, Eckert M, Gres V, Lagies S, Gorka O, Rambold AS, Buescher JM, Kammerer B, Lachmann N, Prinz M, Groß O, Pearce EJ, Becher B, Henneke P. 2023 Science Immunol
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Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment |
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease |