B05

Impact of intrauterine inflammation on neonatal dendritic cell development and function

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Graphical abstract for Project B05

In this project, we tackle the question of whether maternal inflammation shapes the dendritic cell (DC) compartment in the offspring via inflammatory cytokines. The project investigates the impact of prenatal inflammation on the origin, phenotype and function of the neonatal DC compartment. The time course of DC responsiveness to maternal inflammation will be characterized using fate mapping.

Team

Publications

RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells

Hamsa Narasimhan, Maria L. Richter, Ramin Shakiba, Nikos E. Papaioannou, Christina Stehle, Kaushikk Ravi Rengarajan, Isabel Ulmert, Arek Kendirli, Clara de la Rosa, Pin-Yu Kuo, Abigail Altman, Philipp Münch, Saba Mahboubi, Vanessa Küntzel, Amina Sayed, Eva-Lena Stange, Jonas Pes, Alina Ulezko Antonova, Carlos-Filipe Pereira, Ludger Klein, Diana Dudziak, Marco Colonna, Natalia Torow, Mathias W. Hornef, Björn E. Clausen, Martin Kerschensteiner, Katharina Lahl, Chiara Romagnani, Maria Colomé-Tatché, and Barbara U. Schraml