Nutrition, host metabolism and the antimicrobial response to enteric infection in the neonatal host
Early infection with the human enteropathogen Salmonella affects the fetal-neonatal transition of the intestinal epithelium. Such infections can therefore influence nutrient digestion, substrate absorption, energy metabolism and microbiota establishment, as well as antimicrobial host defense activation.
In this project, we explore molecular mechanisms of these effects and the resulting influence of altered substrate availability on mucosal antimicrobial properties.
Team
Publications
Salmonella infection accelerates postnatal maturation of the intestinal epitheliumStefan Schlößer, Anna-Lena Ullrich, Nastaran Fazel Modares, Matthias A. Schmitz, Johannes Schöneich, Kaiyi Zhang, Isabel Richter, Laura Robrahn, Sarah Schraven, James S. Nagai, Sven-Bastiaan Haange, Susan A. V. Jennings, Thomas Clavel, Ulrike Rolle-Kampczyk, Fabian Kiessling, Ivan G. Costa, Vanesa Muncan, Urska Repnik, Martin von Bergen, Aline Dupont, and Mathias W. Hornef 2024 PNAS
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Early-life vitamin A treatment rescues neonatal infection-induced durably impaired tolerogenic properties of celiac lymph nodesMangge Zou, Joern Pezoldt, Juliane Mohr, Lars Philipsen, Andrea Leufgen, Vuk Cerovic, Carolin Wiechers, Marina Pils, Diego Ortiz, Lianxu Hao, Juhao Yang, Michael Beckstette, Aline Dupont, Mathias Hornef, Petra Dersch, Till Strowig, Andreas J. Müller, Jens Raila, Jochen Huehn 2024 Cell Reports
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Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal hostKaiyi Zhang, Urska Repnik, Nour Diab, Daniel Friske, Andreas Pütz, Alina Z. Bachmann, Narasimha Murthy Keshava Prasad Gubbi1, Michael Hensel, Konrad U. Förstner, Alexander J. Westermann, Aline Dupont, and Mathias W. Hornef 2024 Journal of Experimental Medicine
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Programmed and environmental determinants driving neonatal mucosal immune developmentNatalia Torow, Timothy W. Hand, Mathias W. Hornef |
M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patchTorow N, Li R, Hitch TCA, Mingels C, Al Bounny S, van Best N, Stange EL, Simons B, Maié T, Rüttger L, Gubbi NMKP, Abbott DA, Benabid A, Gadermayr M, Runge S, Treichel N, Merhof D, Rosshart SP, Jehmlich N, Hand TW, von Bergen M, Heymann F, Pabst O, Clavel T, Tacke F, Lelouard H, Costa IG, Hornef MW 2023 Immunity
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Perinatal development of innate immune topology.Philipp Henneke, Katrin Kierdorf, Lindsay J Hall, Markus Sperandio, Mathias Hornef 2021 eLife
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